Product: | KN-62 | ||||||||
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Catalog Number: | 11303 | ||||||||
CAS Number: | 127191-97-3 | ||||||||
Synonyms: |
(S)-5-Isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester; 1-[N,O-bis(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine |
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Pricing: |
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Formula: | C38H35O6S2 | ||||||||
Chemical Purity: | >95% | ||||||||
Molecular Weight: | 721.84 | ||||||||
Structure: |
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Appearance: | White powder | ||||||||
Category: | Protein Kinase Inhibitors and Activators | ||||||||
Stability: | Stable under recommended storage conditions. | ||||||||
Storage: |
Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. |
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Transportation: |
Non-hazardous for transport |
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Literature References: |
MacLeod, et al., Ca(2+)/Calmodulin kinase II and decreases in intracellular pH are required to activate K(+) channels after substantial swelling in villus epithelial cells. J. Membr. Biol. 172, 59-66, (1999); Fan, et al., Inhibition of calcium/calmodulin-dependent protein kinase II in rat hippocampus attenuates morphine tolerance and dependence. Mol. Pharmacol. 56, 39-45, (1999); Communi, et al., Calcium-calmodulin-dependent protein kinase II and protein kinase C-mediated phosphorylation and activation of D-myo-inositol 145-trisphosphate 3-kinase B in astrocytes. J. Biol. Chem. 274, 14734-14742, (1999) |
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MSDS: | |||||||||
Description: |
Selectively inhibits rat brain Ca2+/calmodulin-dependent protein kinase II. |