Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2-8°C

IATA: Hazard Class: 6.1; UN Number: UN2811; Packing Group: III; Shipping Name: Toxic solid, organic, n.o.s. (Amitriptyline hydrochloride)

Kabir-ud-Din, , et al., Self-association Behavior Of Amitriptyline Hydrochloride As A Function Of Temperature And Additive (inorganic Salts And Ureas) Concentration. Colloids Surf., B 82, 87-94, (2011); Huangfu, D., et al., Sympatholytic effect of tricyclic antidepressants: site and mechanism of action in anesthetized rats. Am. J. Physiol. 268, R1429-R1441, (1995); Teschemacher, A.G., et al., Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline. Br. J. Pharmacol. 128, 479-485, (1999); Stanton, T., et al., Antagonism of the five cloned human muscarinic cholinergic receptors expressed in CHO-K1 cells by antidepressants and antihistaminics. Biochem. Pharmacol. 45, 2352-2354, (1993); Sanchez, C., and Hyttel, J., Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cell. Mol. Neurobiol. 19, 467-489, (1999); Torres, G.E., et al., Plasma membrane monoamine transporter: structure, regulation and function. Nat. Rev. Neurosci. 4, 13-25, (2003); Merck 14,487

Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with K_is of 100 nM and 14.7 nM, respectively; high in vitro affinity for α₁-adrenoceptors, serotonin and muscarinic acetylcholine receptors.