Product: | Hydroxytyrosol | ||||
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Catalog Number: | 32087 | ||||
CAS Number: | 10597-60-1 | ||||
Pricing: |
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Formula: | C8H10O3 | ||||
Chemical Purity: | >98% | ||||
Molecular Weight: | 154.16 | ||||
Structure: | |||||
Category: | Anti-cancer compounds | ||||
Literature References: |
Kohyama, N., et al. 1997. Biosci. Biotechnol. Biochem. 61: 347-350; 2. Manna, C., et al. 1997. J. Nutr. 127: 286-292; Palmerini, C.A., et al. 2005. J. Nutr. Biochem. 16: 109-113; Guichard, C., et al. 2006. Carcinogenesis. 27: 1812-1827. |
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MSDS: | |||||
Description: |
3,4-Dihydroxyphenyl Ethanol is a phenolic compound present in olive oil, described to inhibit 5-lipoxygenase (5-LO) and 12-lipoxygenase activity (12-LO). 3,4-Dihydroxyphenyl Ethanol is demonstrated to inhibit 5-LO (IC50 = 13 μM) in rat polymorphonuclear leukocytes and 12-LO (IC50 = 4.2 μM) in rat platelets. Oxidative damage induced by H2O2 or a xanthine/xanthine oxidase system on human Caco-2 cells was strongly suppressed by exposure to 3,4-Dihydroxyphenyl Ethanol, indicating reactive oxygen species scavenging activity of the compound. 3,4-Dihydroxyphenyl Ethanol is demonstrated to increase cytosolic Ca2+ levels in human lymphomonocytes. 3,4-Dihydroxyphenyl Ethanol is also described to induce growth arrest and apoptosis in human colon carcinoma HT-29 cells through activation of the serine/threonine protein phosphatase 2A |