Inquire About a Product| Product: | Atorvastatin Calcium Salt | ||||||||
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| Catalog Number: | 5278 | ||||||||
| CAS Number: | 134523-03-8 | ||||||||
| Synonyms: | Lipitor | ||||||||
| Pricing: |
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| Formula: | (C33H34FN2O5)2Ca | ||||||||
| Chemical Purity: | 99.8% | ||||||||
| Molecular Weight: | 1155.34 | ||||||||
| Structure: |
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| Appearance: | White to off-white crystalline powder | ||||||||
| Category: | Atorvastatins | ||||||||
| Stability: | Stable under recommended storage conditions. | ||||||||
| Storage: |
Glass, polyethylene or polypropylene container. Check all containers are clearly labeled and free from leaks. Keep containers securely sealed |
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| Transportation: |
Non-hazardous for transport |
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| Literature References: |
Kearney, A.S., et al. 1993. Pharm. Res. 10: 1461-1465. PMID: 8272408; Heinonen, T.M., et al. 1996. Clin Ther. 18: 853-863. PMID: 8930429; Whitfield, L.R., et al. 2000. Eur J Drug Metab Pharmacokinet. 25: 97-101. PMID: 11112089; Singh, V. and Deedwania, P. 2008. Drugs Today. 44: 455-471. PMID: 18596999 |
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| MSDS: | |||||||||
| Description: |
Atorvastatin Calcium Salt is a selective and competitive HMG-CoA reductase inhibitor, the rate-controlling enzyme of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. Inhibition of HMG-CoA reductase results in a drastic reduction in the production of cholesterol and other isoprenoids. Competitive inhibitors of the reductase are believed to induce the expression of LDL (Low Density Lipoprotein) receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol |