Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2-8°C. Store under inert gas. Store with desiccant

Non-hazardous for transport

Narayan, V., et al., Cooperative Regulation Of The Interferon Regulatory Factor-1 Tumor Suppressor Protein By Core Components Of The Molecular Chaperone Machinery. J. Thorac. Cardiovasc. Surg. 284, 25889-99, (2009); Walshe, T., et al., Inhibition Of VEGF Or TGF-β Signaling Activates Endothelium And Increases Leukocyte Rolling Arterioscler. Thromb. Vasc. Biol. 29, 1185-1192, (2009); Walshe, T.E., et al., Inhibition Of VEGF Or TGF-{beta} Signaling Activates Endothelium And Increases Leukocyte Rolling. Arterioscler. Thromb. Vasc. Biol. 29, 1185-92, (2009); Hancock, C.N., et al. , Identification of novel extracellular signal-regulated kinase docking domain inhibitors. J. Med. Chem. 48, 4586-4595 , (2005)

3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione is extracellular signal-regulated kinase (ERK) docking domain inhibitor. Inhibits ERK binding rather then ERK activity at the ATP domain. IC₅₀ = 25 μM in HeLa, A549, and SUM-159 tumor cells. Currently, no specific inhibitors of the ERK proteins exist. Preferentially binds to ERK2 with a Kd of ~5 μM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1, but exhibits little effect on ERK1/2 phosphorylation by MEK1/2