Product: | 5-Fluorouracil-13C,15N2 | ||||
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Catalog Number: | CN3686 | ||||
Pricing: |
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Formula: | C313CH3F15N2O2 | ||||
Enrichment: | 99%13C, 98%15N | ||||
Molecular Weight: | 133.06 | ||||
Structure: |
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Category: | Labeled Reference Standards | ||||
Literature References: |
Baker S. D.; Verweij J.; Rowinsky E. K.; Donehower R. C.; Schellens J. H.; Grochow L. B.; Sparreboom A., Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001. J. Natl Cancer Inst., 2002, 94 (24):1883–8.; Saam, J; Critchfield G. C.; Hamilton S. A.; Roa B. B.; Wenstrup R. J.; Kaldate R. R., Body surface area-based dosing of 5-fluoruracil results in extensive interindividual variability in 5-fluorouracil exposure in colorectal cancer patients on FOLFOX regimens. Clin Colorectal Cancer., 2011, 10 (3):203-206. |
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MSDS: | |||||
Applications: | A labeled pyrimidine analog. Used in the treatment of anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers. A suicide inhibitor. Works through irreversible inhibition of thymidylate synthase. Also used for actinic keratosis and Bowen's disease. |