Product: 5-Fluorouracil-13C,15N2
Catalog Number: CN3686
Pricing:
1 mg =  $490   (In Stock) Add to Cart
Formula: C313CH3F15N2O2
Enrichment: 99%13C, 98%15N
Molecular Weight: 133.06
Structure: 5-Fluorouracil-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>
Category: Labeled Reference Standards
Literature References:

Baker S. D.; Verweij J.; Rowinsky E. K.; Donehower R. C.; Schellens J. H.; Grochow L. B.; Sparreboom A., Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001. J. Natl Cancer Inst., 2002, 94 (24):1883–8.; Saam, J; Critchfield G. C.; Hamilton S. A.; Roa B. B.; Wenstrup R. J.; Kaldate R. R., Body surface area-based dosing of 5-fluoruracil results in extensive interindividual variability in 5-fluorouracil exposure in colorectal cancer patients on FOLFOX regimens. Clin Colorectal Cancer., 2011, 10 (3):203-206.

MSDS:
Applications: A labeled pyrimidine analog. Used in the treatment of anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers. A suicide inhibitor. Works through irreversible inhibition of thymidylate synthase. Also used for actinic keratosis and Bowen's disease.