Inquire About a Product| Product: | L-Phenylalanine-d8 | ||||
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| Catalog Number: | D1162 | ||||
| CAS Number: | 17942-32-4 | ||||
| Synonyms: | L-Phenyl-d5-alanine-2,3,3-d3 | ||||
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| Formula: | C6D5CD2CD(NH2)COOH | ||||
| Enrichment: | 98%D | ||||
| Structure: |
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| Category: | Labeled Amino Acids and Derivatives | ||||
| Literature References: |
Mortell KH, Anderson DJ, Lynch JJ et al., Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorganic & Medicinal Chemistry Letters, 2006, 16 (5): 1138–41.; Glushakov, AV; Dennis, DM; Morey, TE; Sumners, C; Cucchiara, RF; Seubert, CN; Martynyuk, AE, Specific inhibition of N-methyl-D-aspartate receptor function in rat hippocampal neurons by L-phenylalanine at concentrations observed during phenylketonuria. Molecular psychiatry, 2002, 7 (4): 359–67.; Glushakov, AV; Dennis, DM; Sumners, C; Seubert, CN; Martynyuk, AE, L-phenylalanine selectively depresses currents at glutamatergic excitatory synapses. Journal of neuroscience research, 2003, 72 (1): 116–24. |
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| MSDS: | |||||
| Applications: | A labeled electrically neutral amino acid. Used to form proteins coded for by DNA. A precursor to to the neurotransmitters norepinephrine and dopamine. May be used as an analgesic and antidepressant. A competitive antagonist at the glycine binding site of NMDA receptor and at the glutamate binding site of AMPA receptor. |