Product: | Desmosine-d4 inner salt | ||||
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Catalog Number: | D5724 | ||||
Unlabeled CAS Number: | 11003-57-9 | ||||
Notes: |
Hygroscopic, contains water. See COA |
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Pricing: |
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Enrichment: | d0 = 0.02%, d1 = 0.25%, d2 = 5.19%, d3 = 26.11%, d4 = 65.55%, d5 | ||||
Chemical Purity: | >95% | ||||
Category: | Reference Standards for Inborn Errors | ||||
Literature References: |
Cocci, F., et al., Urinary desmosine excretion is inversely correlated with the extent of emphysema in patients with chronic obstructive pulmonary disease Int. J. Biochem. Cell Biol. 2002, 34:594-604; Cantor, J.O., et al., Measurement of cross-linked elastin synthesis in bleomycin-induced pulmonary fibrosis using a highly sensitive assay for desmosine and isodesmosine J. Lab. Clin. Med., 1984, 103:384-392; Mecham, R.P., and Foster, J.A., A structural model for desmosine cross-linked peptides Biochem. J., 1978, 103:617-625.; Basalyga DM., et al., Elastin degradation and calcification in an abdominal aorta injury model: role of matrix metalloproteinases. Circulation, 2004, 110:3480-3487.; Bailey M., et al., Aluminum chloride pretreatment of elastin inhibits elastolysis by matrix metalloproteinases and leads to inhibition of elastin-oriented calcification. Am. J. Pathol., 2001, 159:1981-1986.; Starcher, B.C. and Galione, M.J. Prep. Biochem. 1975, 5:455. |
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MSDS: | |||||
Applications: | Labeled desmosine. Desmosine concentrations can be measured in urine, plasma, and sputum samples as a marker for elastin breakdown, which can be linked to certain diseases. |